August 16, 2024, Copenhagen, Denmark
Venue: Maersk Tower, 7.15.92, PANUM

Organizer: Lene Juel Rasmussen, Vilhelm Bohr, Zhiquan Li

Danish Center for Healthy Aging
Department of Cellular and Molecular Medicine
University of Copenhagen

Register here

Learn more about the speakers.

Advancing in age poses significant risks for various diseases, including cardiometabolic disorders, cancer, and neurodegenerative conditions. As the global population ages, the prevalence of age-related ailments escalates. Delving into the molecular intricacies of ageing not only enhances our grasp of disease prevention but also facilitates personalized medical interventions and the development of strategies for promoting healthier ageing, all of which carry profound social and economic implications.

In recent times, scientists have made remarkable strides in deciphering the molecular mechanisms underlying ageing. These mechanisms entail a complex interplay of genetic mutations and cellular processes, notably mitochondrial function. Nevertheless, much remains to be uncovered in this field.

On August 16, the Center for Healthy Aging will host a gathering featuring seven speakers who specialize in fundamental molecular and cellular processes pivotal to cellular ageing. They will present recent findings and participate in a dialogue addressing the significant challenges and emerging avenues within this captivating realm of mitochondrial biology research and its implications in aging and neurodegenerative diseases.

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Programme

11:30-12.30
Registration and lunch

12:30-12:35
Welcome and introduction to the symposium by Vilhelm Bohr and Lene Juel Rasmussen

12:35-13:00
Prof. Vilhelm Bohr
Center for Healthy Aging, University of Copenhagen, Denmark

DNA damage signaling to mitochondria in neurodegeneration and aging

13:00-13:25
Prof. Lene Juel Rasmussen
Center for Healthy Aging, University of Copenhagen, Denmark

FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species

13:25-13:50
Dr. Deborah Croteau
Computational Biology & Genomics Core, National Institute on Aging, NIH, USA

Loss of DNA repair in Alzheimer’s disease models alters disease features

13:50-14:15
Prof. Morten Scheibye-Knudsen
Center for Healthy Aging, University of Copenhagen, Denmark

Data driven interventions in human aging

14:15-14:45
Coffee break

14:45-15:05
Dr. Daniela Bakula
Center for Healthy Aging, University of Copenhagen, Denmark

Why do we grow old? Insights from a new premature aging disorder

15:05-15:30
Prof. Tinna Stevnsner
Department of Molecular Biology and Genetics, Aarhus University, Denmark

Regulation of genome maintenance in the aging brain

15:30-15:55
Prof. Yujun Hou
School of Life Sciences and Technology, Tongji University, China

NAD+, mitophagy, and Alzheimer’s disease

16:00-16:20
Coffee break

16:25-16:50
Prof. Jianhuang Xue
School of Life sciences and Technology, Tongji University, China

The discovery and functional study of novel DNA modifications

16:50-17:10
Dr. Zhiquan Li
Center for Healthy Aging, University of Copenhagen, Denmark

Urolithin A extends healthspan in Drosophila

17:10-17:30
Dr. Yuan Li
Center for Healthy Aging, University of Copenhagen, Denmark

Aging in a Dish: Modeling Alzheimer’s disease with iPSC derived brain cells

17:30
Summing up, implications and discussions
(Vilhelm Bohr, Lene Juel Rasmussen, Yujun Hou, Zhiquan Li)

18:00
Dinner